If the Lyra gets recognized and installed in Vista, but fails to show up in ‘My Computer’, its probably because the built-in HDD is disconnected or worse – crashed.
On Windows Vista, Music Transfer Protocol (MTP) is pre-installed so that is unlikely to be the problem. You can also switch the Lyra to ‘Mass Storage’ mode by going into settings menu.

Also, if your Lyra turns on just fine, but displays ‘File System Is Corrupt’ message, for sure the built-in HDD is loose/disconnected/requires formatting/dead.

Also remember to try alternate USB cables to connect the device to computer and alternate USB ports on the computer. Some ports on the computer may not provide enough power for the Lyra to connect and charge itself successfully. This is particularly true if your computer features a lot of bus-powered USB devices.

If the warranty on your device has expired, don’t be afraid to open up the device and inspect the device yourself.

HTH